Diltiazem and anal fissures

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Breakthrough treatment proves 90 success rate on painful anal fissures. In all, 9 studies have looked at how well diltiazem cream or ointment works for treating anal fissures. Only 1 of these studies looked at how well it worked compared with using no treatment. The anal fissure healed completely in 24 out of 30 adults who were using the diltiazem ointment compared with 10 out of 30 adults who were not using anything. Background chronic anal fissure has traditionally been treated surgically. Initial enthusiasm for chemical sphincterotomy has waned because of poor outcomes with glyceryl trinitrate ointment. Objective the treatment of anal fissures has evolved over the last 5 years with the development of topical treatments aimed at reducing sphincter hypertonia. This is thought to improve anal mucosal blood flow and promote healing of the fissure. This study reports the use of topical diltiazem in patients with chronic anal fissures that have failed previous treatment with topical 0.   an anal fissure is a small tear (like a cut) in the lining of the anal canal. This small cut may cause severe pain and some bright red blood after bowel movements might be present. Anal fissures are notoriously hard to treat as their genesis isnt completely clear. At research article open access formulation and evaluation of diltiazem hydrochloride gels for the treatment of anal fissures sanju dhawan 1, bikash medhi 2, sunny chopra 1 1 university institute of pharmaceutical sciences, center for advanced studies, panjab university, chandigarh, india. Diltiazem and lidocaine are important medications in the treatment of anal fissures. Diltiazem relaxes the anal sphincter to aid in the healing process. Doctors avoid prescribing narcotic pain medications for anal fissures because narcotics can cause constipation, which could worsen anal fissures. After diltiazem therapy for fissure, 59 of patients required further treatment (medical andor surgical) over the average 2year period of followup. Breakthrough treatment proves 90 success rate on painful anal fissures.

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